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Sarka Anal [CRACKED]
Background & aims: Restorative proctocolectomy with ileal pouch-anal anastomosis is a surgical procedure in patients with ulcerative colitis refractory to medical therapies. Pouchitis, the most common complication, is inflammation of the pouch of unknown etiology. To define how the intestinal immune system is distinctly organized during pouchitis, we analyzed tissues from patients with and without pouchitis and from patients with ulcerative colitis using single-cell RNA sequencing (scRNA-seq).
sarka anal
Methods: We examined pouch lamina propria CD45+ hematopoietic cells from intestinal tissues of ulcerative colitis patients with (n = 15) and without an ileal pouch-anal anastomosis (n = 11). Further in silico meta-analysis was performed to generate transcriptional interaction networks and identify biomarkers for patients with inflamed pouches.
Conclusions: Features of intestinal inflammation during pouchitis and ulcerative colitis are similar, which may have clinical implications for the management of pouchitis. scRNA-seq enables meta-analysis of multiple studies, which may facilitate the identification of biomarkers to personalize therapy for patients with IBD. The processed single cell count tables are provided in Gene Expression Omnibus; GSE162335. Raw sequence data are not public and are protected by controlled-access for patient privacy.
@articleSarkar2021,abstract = Coral reefs can undergo relatively rapid changes in the dominant biota, a phenomenon referred to as phase shift. Degradation of coral reefs is often associated with changes in community structure towards a macroalgae-dominated reef ecosystem due to the reduction in herbivory caused by overfishing. We investigate the coral-macroalgal phase shift due to the effects of harvesting of herbivorous reef fish by means of a continuous time model in the food chain. Conditions for local asymptotic stability of steady states are derived. We have shown that under certain conditions the system is uniformly persistent in presence of all the organisms. Moreover, it is shown that the system undergoes a Hopf bifurcation when the carrying capacity of macroalgae crosses certain critical value. Computer simulations have been carried out to illustrate different analytical results.,author = Sarkar, Ikbal Hossein, Bhattacharyya, Joydeb, Pal, Samares,journal = Applications of Mathematics,keywords = phase shift; coral bleaching; harvesting; Hopf bifurcation,language = eng,number = 2,pages = 233-268,publisher = Institute of Mathematics, Academy of Sciences of the Czech Republic,title = Herbivore harvesting and alternative steady states in coral reefs,url = ,volume = 66,year = 2021,
TY - JOURAU - Sarkar, Ikbal HosseinAU - Bhattacharyya, JoydebAU - Pal, SamaresTI - Herbivore harvesting and alternative steady states in coral reefsJO - Applications of MathematicsPY - 2021PB - Institute of Mathematics, Academy of Sciences of the Czech RepublicVL - 66IS - 2SP - 233EP - 268AB - Coral reefs can undergo relatively rapid changes in the dominant biota, a phenomenon referred to as phase shift. Degradation of coral reefs is often associated with changes in community structure towards a macroalgae-dominated reef ecosystem due to the reduction in herbivory caused by overfishing. We investigate the coral-macroalgal phase shift due to the effects of harvesting of herbivorous reef fish by means of a continuous time model in the food chain. Conditions for local asymptotic stability of steady states are derived. We have shown that under certain conditions the system is uniformly persistent in presence of all the organisms. Moreover, it is shown that the system undergoes a Hopf bifurcation when the carrying capacity of macroalgae crosses certain critical value. Computer simulations have been carried out to illustrate different analytical results.LA - engKW - phase shift; coral bleaching; harvesting; Hopf bifurcationUR - ER - 041b061a72